Babe Ruth has hit the most homers in a decade, with 467 home runs in the 1920s.

Interpreted as:

MLB most home runs by a player by decade

	NAME	HR	DECADE	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Babe Ruth B. Ruth	467	1920s	1,399	4,884	1,365	1,734	314	82	1,338	1,240	27	795	88		6,224	3,613	863	73				.355	.488	.740	1.228	1701	932.6	.535	206	884.9
2	Alex Rodriguez A. Rodriguez	435	2000s	1,524	5,732	1,190	1,740	285	16	1,243	850	125	1,243	179	37	6,768	3,362	736	0	61	82	149	.304	.401	.587	.988	1325	491.3	.416	154	459.7
3	Jimmie Foxx J. Foxx	415	1930s	1,470	5,495	1,244	1,845	316	87	1,403	1,015	7	876	65		6,552	3,580	818	35			17	.336	.440	.652	1.091	1555	726.8	.479	166	611.7
4	Mark McGwire M. McGwire	405	1990s	1,221	4,002	791	1,071	172	1	956	951	52	1,040	9	5	5,054	2,460	578	2	47	118	91	.268	.411	.615	1.025	1037	427.7	.430	166	421.9
5	Harmon Killebrew H. Killebrew	393	1960s	1,429	4,994	864	1,331	183	17	1,013	970	35	1,029	12	8	6,042	2,727	593	0	43	98	133	.267	.387	.546	.933	1090	441	.406	154	376.4
6	Ken Griffey Jr. K. Griffey Jr.	382	1990s	1,408	5,377	1,002	1,622	297	30	1,091	703	45	901	151	53	6,182	3,125	709	5	52	162	105	.302	.384	.581	.965	1144	397.1	.407	147	366.5
7	Hank Aaron H. Aaron	375	1960s	1,540	5,912	1,091	1,819	309	45	1,107	672	12	723	204	60	6,661	3,343	729	1	64	160	146	.308	.376	.565	.941	1198	486.9	.406	159	448.5
8	Jim Thome J. Thome	368	2000s	1,368	4,629	877	1,255	231	8	986	973	37	1,431	3	9	5,681	2,606	607	0	42	112	81	.271	.399	.563	.962	1057	355	.404	145	321.6
9	Albert Pujols A. Pujols	366	2000s	1,399	5,146	1,071	1,717	387	14	1,112	811	69	570	61	30	6,082	3,230	767	1	55	198	180	.334	.427	.628	1.055	1295	551.8	.437	169	537.6
10	Barry Bonds B. Bonds	361	1990s	1,434	4,894	1,091	1,478	299	42	1,076	1,146	45	747	343	94	6,146	2,944	702	1	60	257	96	.302	.434	.602	1.036	1270	528.6	.434	172	538.6
11	Albert Belle A. Belle	351	1990s	1,336	5,076	881	1,520	344	16	1,099	619	49	838	86	34	5,817	2,949	711	4	69	80	172	.299	.376	.581	.957	1077	366.4	.406	145	339.6
12	Willie Mays W. Mays	350	1960s	1,498	5,459	1,050	1,635	259	53	1,003	681	22	783	126	42	6,213	3,050	662	6	45	103	131	.300	.377	.559	.935	1120	453.5	.406	158	415
13	Manny Ramirez M. Ramirez	348	2000s	1,358	4,931	933	1,562	328	11	1,106	828	69	1,085	10	9	5,874	2,956	687	0	46	174	148	.317	.419	.599	1.018	1190	466.7	.424	158	433.5
14	Lou Gehrig L. Gehrig	347	1930s	1,397	5,255	1,257	1,802	328	91	1,360	1,028	30	439	72		6,339	3,353	766	26			2	.343	.453	.638	1.091	1522	719.6	.481	174	666.9
15	Nelson Cruz N. Cruz	346	2010s	1,385	5,193	774	1,461	275	9	961	511	64	1,302	50	23	5,812	2,792	630	1	43	52	123	.281	.350	.538	.888	953	282.4	.376	138	263.4
16	Juan Gonzalez J. Gonzalez	339	1990s	1,224	4,771	785	1,412	279	19	1,068	338	48	930	21	15	5,215	2,746	637	0	58	63	125	.296	.345	.576	.920	893	259.1	.390	133	219.1
17	Edwin Encarnacion E. Encarnacion	335	2010s	1,360	4,963	819	1,308	251	5	956	689	56	979	41	9	5,761	2,574	591	0	53	44	142	.264	.356	.519	.875	925	260.5	.372	135	233.8
18	Sammy Sosa S. Sosa	332	1990s	1,351	5,106	814	1,366	198	35	928	417	34	1,322	217	94	5,605	2,630	565	12	36	62	115	.268	.325	.515	.840	818	133.2	.358	115	112.4
19	Rafael Palmeiro R. Palmeiro	328	1990s	1,526	5,848	965	1,747	343	23	1,068	707	47	792	67	29	6,681	3,120	694	11	68	93	132	.299	.375	.534	.908	1144	337.3	.390	136	306.5
20	Duke Snider D. Snider	326	1950s	1,418	5,219	970	1,605	274	57	1,031	711	11	851	77	48	6,010	2,971	657	44	25	74	132	.308	.390	.569	.959	1122	425.7	.420	147	353.8
21	Carlos Delgado C. Delgado	324	2000s	1,368	4,951	863	1,416	326	12	1,045	796	126	1,121	9	3	5,938	2,738	662	0	65	151	108	.286	.394	.553	.947	1069	335.2	.397	141	309.5
22	Barry Bonds B. Bonds	317	2000s	986	2,871	772	925	178	12	697	1,128	53	427	54	9	4,072	2,078	507	0	20	390	49	.322	.517	.724	1.241	1059	552.8	.490	203	542
23	Adam Dunn A. Dunn	316	2000s	1,290	4,417	780	1,101	230	8	777	913	62	1,433	59	20	5,417	2,295	554	2	23	97	65	.249	.383	.520	.903	913	251.7	.384	131	211.4
24	Frank Robinson F. Robinson	316	1960s	1,468	5,265	1,013	1,603	309	44	1,011	778	113	749	145	55	6,209	2,948	669	0	53	143	141	.304	.402	.560	.962	1167	500.7	.416	164	451.2
25	Vladimir Guerrero V. Guerrero	315	2000s	1,432	5,415	929	1,751	324	30	1,037	569	66	670	147	67	6,094	3,080	669	0	44	213	190	.323	.392	.569	.960	1107	355.6	.399	142	328.3