Mike Mussina had a record of 123-72 with an ERA of 3.88 and 1,278 strikeouts in 249 appearances for the Yankees in his career.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | M. Mussina | 2001 |  NYY | 34 | 17 | 11 | .607 | 34 | 3.15 | 214 | 4 | 3 | 0 | 228.2 | 202 | 80 | 87 | 20 | 42 | 4 | 0 | 2 | 909 | 6 | 8.42 | 1.65 | 5.10 | 0.79 | 23.5 | 4.6 | 1.07 | .289 | 3.42 | 72 | 2.91 | 66 | 7.95 | 38.5 |
| 2 | | M. Mussina | 2002 | NYY | 33 | 18 | 10 | .643 | 33 | 4.05 | 182 | 2 | 2 | 0 | 215.2 | 208 | 97 | 103 | 27 | 48 | 5 | 0 | 1 | 886 | 7 | 7.60 | 2.00 | 3.79 | 1.13 | 20.5 | 5.4 | 1.19 | .290 | 4.30 | 92 | 3.63 | 83 | 8.68 | 17.5 |
| 3 | | M. Mussina | 2003 | NYY | 31 | 17 | 8 | .680 | 31 | 3.40 | 195 | 2 | 1 | 0 | 214.2 | 192 | 81 | 86 | 21 | 40 | 3 | 0 | 4 | 855 | 4 | 8.18 | 1.68 | 4.88 | 0.88 | 22.8 | 4.7 | 1.08 | .287 | 3.61 | 76 | 3.08 | 69 | 8.05 | 32.9 |
| 4 | | M. Mussina | 2004 | NYY | 27 | 12 | 9 | .571 | 27 | 4.59 | 132 | 1 | 0 | 0 | 164.2 | 178 | 84 | 91 | 22 | 40 | 2 | 0 | 1 | 697 | 5 | 7.21 | 2.19 | 3.30 | 1.20 | 18.9 | 5.7 | 1.32 | .311 | 4.97 | 101 | 3.94 | 88 | 9.73 | 9.8 |
| 5 | | M. Mussina | 2005 | NYY | 30 | 13 | 8 | .619 | 30 | 4.41 | 142 | 2 | 2 | 0 | 179.2 | 199 | 88 | 93 | 23 | 47 | 7 | 0 | 0 | 766 | 2 | 7.11 | 2.35 | 3.02 | 1.15 | 18.5 | 6.1 | 1.37 | .322 | 4.66 | 102 | 3.99 | 92 | 9.97 | 6.5 |
| 6 | | M. Mussina | 2006 | NYY | 32 | 15 | 7 | .682 | 32 | 3.51 | 172 | 1 | 0 | 0 | 197.1 | 184 | 77 | 88 | 22 | 35 | 5 | 0 | 1 | 804 | 3 | 7.84 | 1.60 | 4.91 | 1.00 | 21.4 | 4.4 | 1.11 | .284 | 4.01 | 77 | 3.45 | 77 | 8.39 | 23.3 |
| 7 | | M. Mussina | 2007 | NYY | 28 | 11 | 10 | .524 | 27 | 5.15 | 91 | 0 | 0 | 0 | 152.0 | 188 | 87 | 90 | 14 | 35 | 4 | 0 | 2 | 656 | 1 | 5.39 | 2.07 | 2.60 | 0.83 | 13.9 | 5.3 | 1.47 | .340 | 5.33 | 114 | 4.00 | 90 | 11.13 | 7.3 |
| 8 | | M. Mussina | 2008 | NYY | 34 | 20 | 9 | .690 | 34 | 3.37 | 150 | 0 | 0 | 0 | 200.1 | 214 | 75 | 85 | 17 | 31 | 8 | 0 | 3 | 819 | 4 | 6.74 | 1.39 | 4.84 | 0.76 | 18.3 | 3.8 | 1.22 | .321 | 3.82 | 78 | 3.31 | 77 | 9.61 | 22.3 |
| Total | 249 | 123 | 72 | .631 | 248 | 3.88 | 1,278 | 12 | 8 | 0 | 1553.0 | 1,565 | 669 | 723 | 166 | 318 | 38 | 0 | 14 | 6,392 | 32 | 7.41 | 1.84 | 4.02 | 0.96 | 20.0 | 5.0 | 1.21 | .305 | 4.19 | 87 | 3.50 | 79 | 9.07 | 158.1 |
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