12 pitchers are tied for the fewest career wins when winning 100+ games, with 100 wins. The first three are José Berríos, Brett Tomko and Zane Smith.

Interpreted as:

fastest pitchers to 100 or more regular-season wins

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	José Berríos J. Berríos	100	78	.562	250	249	4.08	1,371	5	1	0	1439.2	1,347	652	695	199	432	91	0	5	6,053	35	8.57	2.70	3.17	1.24	22.6	7.1	1.24	.290	4.34	97	4.15	98	8.42	19
2	Brett Tomko B. Tomko	100	103	.493	397	266	4.65	1,209	13	2	2	1816.0	1,898	939	1,011	255	582	37	39	52	7,824	63	5.99	2.88	2.08	1.26	15.5	7.4	1.37	.286	5.01	109	4.59	106	9.41	-56
3	Zane Smith Z. Smith	100	115	.465	360	291	3.74	1,011	35	16	3	1919.1	1,980	798	933	122	583	31	16	55	8,077	28	4.74	2.73	1.73	0.57	12.5	7.2	1.34	.294	4.37	94	3.59	92	9.28	70.1
4	Mario Soto M. Soto	100	92	.521	297	224	3.47	1,449	72	13	4	1730.1	1,395	667	732	172	657	28	20	50	7,147	37	7.54	3.42	2.21	0.89	20.3	9.2	1.19	.253	3.81	93	3.52	95	7.26	32.5
5	Moose Haas M. Haas	100	83	.546	266	252	4.01	853	56	8	2	1655.0	1,717	738	806	162	436	10	8	36	6,928	40	4.64	2.37	1.96	0.88	12.3	6.3	1.30	.284	4.38	102	3.77	96	9.34	27.6
6	Randy Jones R. Jones	100	123	.448	305	285	3.42	735	73	19	2	1933.0	1,915	735	875	129	503	18	11	88	8,069	19	3.42	2.34	1.46	0.60	9.1	6.2	1.25	.267	4.07	99	3.55	101	8.92	-11
7	Dick Tidrow D. Tidrow	100	94	.515	620	138	3.68	975	32	5	55	1746.2	1,705	715	807	163	579	43	244	112	7,412	32	5.02	2.98	1.68	0.84	13.2	7.8	1.31	.273	4.16	99	3.77	101	8.79	-8.1
8	Clyde Wright C. Wright	100	111	.474	329	235	3.50	667	67	9	3	1728.2	1,679	672	764	143	550	23	34	44	7,252	45	3.47	2.86	1.21	0.74	9.2	7.6	1.29	.262	3.98	105	3.81	111	8.74	-81.2
9	Dave Giusti D. Giusti	100	93	.518	668	133	3.60	1,103	35	9	145	1716.2	1,654	687	764	126	570	15	380	109	7,251	87	5.78	2.99	1.94	0.66	15.2	7.9	1.30	.281	4.01	105	3.22	96	8.67	24.2
10	Tex Carleton T. Carleton	100	76	.568	293	202	3.91	808	91	16	8	1607.1	1,630	698	770	105	561	38	64		6,922	38	4.52	3.14	1.44	0.59	11.7	8.1	1.36	.282	4.31	101	3.97	99	9.13	9.9
11	Monte Pearson M. Pearson	100	61	.621	224	191	4.00	703	94	5	4	1429.2	1,392	635	721	82	740	6	24		6,259	43	4.43	4.66	0.95	0.52	11.2	11.8	1.49	.277	4.54	89	4.35	99	8.76	3.5
12	Ray Fisher R. Fisher	100	94	.515	278	207	2.82	680	110	19	7	1755.2	1,667	550	727	33	481	43	48		7,058	30	3.49	2.47	1.41	0.17	9.6	6.8	1.22	.281	3.73	95	2.88	96	8.55	23
13	Michael Wacha M. Wacha	101	65	.608	284	263	3.88	1,316	2	2	0	1486.2	1,433	641	684	180	470	38	4	18	6,265	41	7.97	2.85	2.80	1.09	21.0	7.5	1.28	.294	4.14	96	3.98	98	8.68	10.9
14	Joe Blanton J. Blanton	101	97	.510	427	252	4.38	1,284	8	3	2	1767.2	1,896	860	914	223	467	41	51	44	7,544	41	6.54	2.38	2.75	1.14	17.0	6.2	1.34	.303	4.65	106	4.15	99	9.65	7.4
15	Kelvim Escobar K. Escobar	101	91	.526	411	202	4.15	1,310	10	4	59	1507.0	1,461	695	755	137	611	47	132	28	6,483	54	7.82	3.65	2.14	0.82	20.2	9.4	1.37	.302	4.51	89	3.85	85	8.73	114.2
16	Shawn Estes S. Estes	101	93	.521	283	281	4.71	1,210	14	8	0	1678.1	1,708	879	950	158	858	57	0	36	7,403	79	6.49	4.60	1.41	0.85	16.3	11.6	1.53	.303	5.09	110	4.49	103	9.16	-23.6
17	Eric Show E. Show	101	89	.532	332	235	3.66	971	35	11	7	1655.0	1,526	673	739	171	610	46	37	49	6,968	36	5.28	3.32	1.59	0.93	13.9	8.8	1.29	.262	4.02	102	4.12	110	8.30	-70.3
18	Jim Barr J. Barr	101	112	.474	454	252	3.56	741	64	20	12	2065.1	2,170	816	908	161	469	30	75	74	8,612	22	3.23	2.04	1.58	0.70	8.6	5.4	1.28	.279	3.96	95	3.63	100	9.46	-5.2
19	Don Mossi D. Mossi	101	80	.558	460	165	3.43	932	55	8	50	1548.0	1,493	590	672	156	385	19	148	34	6,464	12	5.42	2.24	2.42	0.91	14.4	6.0	1.21	.269	3.91	88	3.40	86	8.68	96.2
20	Bob Turley B. Turley	101	85	.543	310	237	3.64	1,265	78	24	13	1712.2	1,366	693	753	140	1,068	56	38	21	7,447	39	6.65	5.61	1.18	0.74	17.0	14.3	1.42	.249	3.96	98	4.02	108	7.18	-66.7
21	Johnny Klippstein J. Klippstein	101	118	.461	711	161	4.24	1,158	37	6	65	1967.2	1,915	927	1,059	203	978	70	275	70	8,656	97	5.30	4.47	1.18	0.93	13.4	11.3	1.47	.274	4.84	106	4.24	106	8.76	-52.7
22	Alex Kellner A. Kellner	101	112	.474	321	250	4.41	816	99	9	6	1849.1	1,925	906	1,015	184	747	37	37	11	8,023	53	3.97	3.64	1.09	0.90	10.2	9.3	1.44	.279	4.94	107	4.16	101	9.37	-9.6
23	Si Johnson S. Johnson	101	165	.380	492	272	4.09	840	108	13	15	2281.1	2,510	1,036	1,226	121	687	36	115		9,903	26	3.31	2.71	1.22	0.48	8.5	6.9	1.40	.291	4.84	109	3.77	99	9.90	8.4
24	Ray Benge R. Benge	101	129	.439	346	248	4.52	655	102	12	19	1875.1	2,177	941	1,108	132	598	30	65		8,278	14	3.14	2.87	1.10	0.63	7.9	7.2	1.48	.298	5.32	105	4.32	99	10.45	17.3
25	Lefty Stewart L. Stewart	101	98	.508	279	216	4.19	503	107	8	8	1722.0	1,895	802	932	118	498	18	43		7,402	6	2.63	2.60	1.01	0.62	6.8	6.7	1.39	.284	4.87	94	4.30	97	9.90	25