The 2021 pitchers for the Cubs included Anderson Espinoza, Jonathan Holder, Brailyn Marquez, Alexander Vizcaino and Kyle Hendricks.

	NO.	NAME	POS	HEIGHT	WEIGHT	DOB	AGE	BIRTHPLACE
1	15	Cory Abbott C. Abbott	P	6'2"	220	9/20/1995	25	San Diego, CA
2	60	Jason Adam J. Adam	P	6'4"	225	8/4/1991	29	Overland Park, KS
3	73	Adbert Alzolay A. Alzolay	P	6'0"	179	3/1/1995	26	Puerto Ordaz, Venezuela
4	49	Jake Arrieta J. Arrieta	P	6'4"	225	3/6/1986	35	Farmington, MO
5	41	Joe Biagini J. Biagini	P	6'5"	235	5/29/1990	31	Menlo Park, CA
6	48	Rex Brothers R. Brothers	P	6'0"	205	12/18/1987	33	Unionville, TN
7	39	Andrew Chafin A. Chafin	P	6'2"	225	6/17/1990	31	Kettering, OH
8	27	Zach Davies Z. Davies	P	6'0"	155	2/7/1993	28	Puyallup, WA
9	57	Scott Effross S. Effross	P	6'2"	202	12/28/1993	27	Twinsburg, OH
10		Anderson Espinoza A. Espinoza	P	6'0"	160	3/9/1998	23	Caracas, Venezuela
11	28	Kyle Hendricks K. Hendricks	P	6'3"	190	12/7/1989	31	Newport Beach, CA
12	12	Codi Heuer C. Heuer	P	6'5"	195	7/3/1996	24	Missoula, MT
13	52	Jonathan Holder J. Holder	P	6'2"	235	6/9/1993	28	Gulfport, MS
14	65	Jake Jewell J. Jewell	P	6'3"	200	5/16/1993	28	Norman, OK
15	46	Craig Kimbrel C. Kimbrel	P	6'0"	210	5/28/1988	33	Huntsville, AL
16	36	Dillon Maples D. Maples	P	6'2"	230	5/9/1992	29	West End, NC
17	61	Brailyn Marquez B. Marquez	P	6'4"	185	1/30/1999	22	Santo Domingo, Dominican Republic
18	74	Trevor Megill T. Megill	P	6'8"	235	12/5/1993	27	Long Beach, CA
19	64	Ryan Meisinger R. Meisinger	P	6'4"	235	5/4/1994	27	Prince Frederick, MD
20	29	Shelby Miller S. Miller	P	6'3"	225	10/10/1990	30	Houston, TX
21	30	Alec Mills A. Mills	P	6'4"	190	11/30/1991	29	Clarksville, TN
22	47	Adam Morgan A. Morgan	P	6'1"	200	2/27/1990	31	Tampa, FL
23	45	Tommy Nance T. Nance	P	6'6"	235	3/19/1991	30	Long Beach, CA
24	39	Manuel Rodríguez M. Rodríguez	P	5'11"	205	8/6/1996	24	Merida, Mexico
25	59	Michael Rucker M. Rucker	P	6'1"	195	4/27/1994	27	Columbus, MS