Pepe Reina had 25 clean sheets and 100 goals allowed in 81 appearances in the Premier League against Big Six opponents in his career.

Pepe Reina stats against the big six in his career

	NAME	DATE	CLUB		OPP	MIN	GC	SV-PK	CS	OG	YC	RC
1	Pepe Reina P. Reina	9/10/2005	Liverpool	@	Tottenham	90	0	0	1	0	0	0
2	Pepe Reina P. Reina	9/18/2005	Liverpool	vs	Man United	90	0	0	1	0	0	0
3	Pepe Reina P. Reina	10/2/2005	Liverpool	vs	Chelsea	90	4	0	0	0	0	0
4	Pepe Reina P. Reina	11/26/2005	Liverpool	@	Man City	90	0	0	1	0	0	0
5	Pepe Reina P. Reina	1/14/2006	Liverpool	vs	Tottenham	90	0	0	1	0	0	0
6	Pepe Reina P. Reina	1/22/2006	Liverpool	@	Man United	90	1	0	0	0	0	0
7	Pepe Reina P. Reina	2/5/2006	Liverpool	@	Chelsea	81	2	0	0	0	0	1
8	Pepe Reina P. Reina	2/26/2006	Liverpool	vs	Man City	90	0	0	1	0	0	0
9	Pepe Reina P. Reina	3/12/2006	Liverpool	@	Arsenal	90	2	0	0	0	0	0
10	Pepe Reina P. Reina	9/17/2006	Liverpool	@	Chelsea	90	1	0	0	0	0	0
11	Pepe Reina P. Reina	9/23/2006	Liverpool	vs	Tottenham	90	0	0	1	0	0	0
12	Pepe Reina P. Reina	10/22/2006	Liverpool	@	Man United	90	2	0	0	0	0	0
13	Pepe Reina P. Reina	11/12/2006	Liverpool	@	Arsenal	90	3	0	0	0	0	0
14	Pepe Reina P. Reina	11/25/2006	Liverpool	vs	Man City	90	0	0	1	0	0	0
15	Pepe Reina P. Reina	12/30/2006	Liverpool	@	Tottenham	90	0	0	1	0	0	0
16	Pepe Reina P. Reina	1/20/2007	Liverpool	vs	Chelsea	90	0	0	1	0	0	0
17	Pepe Reina P. Reina	3/3/2007	Liverpool	vs	Man United	90	1	0	0	0	0	0
18	Pepe Reina P. Reina	3/31/2007	Liverpool	vs	Arsenal	90	1	0	0	0	0	0
19	Pepe Reina P. Reina	4/14/2007	Liverpool	@	Man City	90	0	0	1	0	0	0
20	Pepe Reina P. Reina	8/19/2007	Liverpool	vs	Chelsea	90	1	0	0	0	0	0
21	Pepe Reina P. Reina	10/7/2007	Liverpool	vs	Tottenham	90	2	0	0	0	0	0
22	Pepe Reina P. Reina	10/28/2007	Liverpool	vs	Arsenal	90	1	0	0	0	0	0
23	Pepe Reina P. Reina	12/16/2007	Liverpool	vs	Man United	90	1	0	0	0	0	0
24	Pepe Reina P. Reina	12/30/2007	Liverpool	@	Man City	90	0	0	1	0	0	0
25	Pepe Reina P. Reina	2/10/2008	Liverpool	@	Chelsea	90	0	0	1	0	0	0
	Total					7,281	100	1	25	1	1	1