Hugo Lloris has made the most career appearances by a Tottenham player in the Premier League, with 361 appearances.

most appearances by a player for spurs premier league

	NAME	M	MIN	START	G	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Hugo Lloris H. Lloris	361	32,222	361	0	0.00	1	1	0
2	Son Heung-min S. Heung-min	331	24,026	275	127	0.38	71	198	4	1	723	338	30	13,188	1,407	176
3	Harry Kane H. Kane	317	26,819	301	213	0.67	47	260	33
4	Darren Anderton D. Anderton	299	24,114	273	34	0.11	66	100	5
5	Jermain Defoe J. Defoe	276	17,181	182	91	0.33	19	110	4
6	Eric Dier E. Dier	274	22,887	256	12	0.04	9	21	0	0	158	38	5	18,940	168	9
7	Ledley King L. King	268	23,121	264	10	0.04	8	18	0
8	Aaron Lennon A. Lennon	266	19,494	220	26	0.10	45	71	0
9	Sol Campbell S. Campbell	255	21,649	246	10	0.04	9	19	0
10	Ian Walker I. Walker	240	21,393	238	0	0.00	2	2	0
11	Robbie Keane R. Keane	238	16,849	189	91	0.38	22	113	16
12	Ben Davies B. Davies	237	17,711	193	7	0.03	16	23	0	0	114	29	3	14,555	220	10
13	Michael Dawson M. Dawson	236	19,708	221	7	0.03	5	12	0
14	Teddy Sheringham T. Sheringham	236	20,643	230	97	0.41	44	141	18
15	Jan Vertonghen J. Vertonghen	232	20,130	227	6	0.03	4	10	0
16	Christian Eriksen C. Eriksen	226	18,321	206	51	0.23	59	110	0
17	Stephen Carr S. Carr	226	19,719	222	7	0.03	15	22	0
18	Kyle Walker K. Walker	183	15,825	180	4	0.02	15	19	0
19	Dele Alli D. Alli	181	13,458	155	51	0.28	34	85	3	0	334	134	8	9,246	537	34
20	Moussa Dembélé M. Dembélé	181	11,909	137	7	0.04	6	13	0
21	Erik Lamela E. Lamela	177	9,323	95	17	0.10	23	40	0
22	Toby Alderweireld T. Alderweireld	174	15,323	172	8	0.05	4	12	0	0	123	36	3	12,393	99	3
23	Justin Edinburgh J. Edinburgh	174	13,647	154	0	0.00	7	7	0
24	Gareth Bale G. Bale	166	12,829	146	53	0.32	22	75	0
25	Colin Calderwood C. Calderwood	163	13,537	152	6	0.04	0	6	0