Manchester United had their highest goal differential in a Premier League match versus Arsenal on August 28, 2011, with a differential of 6 goals.

man utd biggest margin of victory in a game vs arsenal

	CLUB	GD	DATE		OPP	RESULT	G	SH	SOT	PASS	PASS-ATT	POSS%	FOUL	YC	RC	SUBS
1	Man United	6	8/28/2011	vs	Arsenal	W 8-2	8	25	14		533	56.3	9	2	0	3
2	Man United	5	2/25/2001	vs	Arsenal	W 6-1	6							0	0	2
3	Man United	3	3/22/1995	vs	Arsenal	W 3-0	3							1	0	0
4	Man United	2	9/4/2022	vs	Arsenal	W 3-1	3	10	6	245	316	39.5	13	3	0	4
5	Man United	2	12/2/2017	@	Arsenal	W 3-1	3	8	4	147	222	24.9	10	2	1	3
6	Man United	2	1/31/2010	@	Arsenal	W 3-1	3	13	4		425	46.3	12	0	0	3
7	Man United	2	4/9/2006	vs	Arsenal	W 2-0	2							3	0	2
8	Man United	2	2/1/2005	@	Arsenal	W 4-2	4							4	1	3
9	Man United	2	10/24/2004	vs	Arsenal	W 2-0	2							2	0	2
10	Man United	2	12/7/2002	vs	Arsenal	W 2-0	2							1	0	0
11	Man United	1	12/2/2021	vs	Arsenal	W 3-2	3	14	10	361	438	44.8	9	1	0	3
12	Man United	1	4/29/2018	vs	Arsenal	W 2-1	2	16	3	543	609	59.2	12	0	0	3
13	Man United	1	2/28/2016	vs	Arsenal	W 3-2	3	7	5	271	355	38.9	21	4	0	3
14	Man United	1	11/22/2014	@	Arsenal	W 2-1	2	12	2	230	317	38.6	8	1	0	3
15	Man United	1	11/10/2013	vs	Arsenal	W 1-0	1	5	2		354	40.5	12	2	0	3
16	Man United	1	11/3/2012	vs	Arsenal	W 2-1	2	14	6		532	47.7	15	5	0	2
17	Man United	1	1/22/2012	@	Arsenal	W 2-1	2	9	6		437	51.4	6	2	0	3
18	Man United	1	12/13/2010	vs	Arsenal	W 1-0	1	17	6		430	46.1	9	0	0	1
19	Man United	1	8/29/2009	vs	Arsenal	W 2-1	2	14	3		424	51.1	22	3	0	2
20	Man United	1	4/13/2008	vs	Arsenal	W 2-1	2	17	7		424	52.4	12	2	0	3
21	Man United	1	8/22/1999	@	Arsenal	W 2-1	2							4	0	3
22	Man United	1	2/19/1997	@	Arsenal	W 2-1	2							2	0	2
23	Man United	1	11/16/1996	vs	Arsenal	W 1-0	1							1	0	0
24	Man United	1	3/20/1996	vs	Arsenal	W 1-0	1							0	0	1
25	Man United	1	9/19/1993	vs	Arsenal	W 1-0	1							2	0	1