Jermain Defoe had a hat trick, 6 goals and an assist in 16 appearances versus Southampton in the Premier League in his career.

Jermain Defoe stats vs southampton in his career

	NAME	DATE	CLUB		OPP	MIN	G	A	XG	XA	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF	FOUL	YC
1	Jermain Defoe J. Defoe	1/30/2002	West Ham	@	Southampton	24	0	0			0									0
2	Jermain Defoe J. Defoe	12/2/2002	West Ham	vs	Southampton	90	0	0			0									0
3	Jermain Defoe J. Defoe	4/5/2003	West Ham	@	Southampton	90	1	0			0									0
4	Jermain Defoe J. Defoe	3/27/2004	Tottenham	@	Southampton	90	0	0			0									0
5	Jermain Defoe J. Defoe	12/18/2004	Tottenham	vs	Southampton	90	3	1			0									0
6	Jermain Defoe J. Defoe	3/5/2005	Tottenham	@	Southampton	90	0	0			0									0
7	Jermain Defoe J. Defoe	10/28/2012	Tottenham	@	Southampton	78	0	0			0									0
8	Jermain Defoe J. Defoe	5/4/2013	Tottenham	vs	Southampton	90	0	0			0									0
9	Jermain Defoe J. Defoe	12/22/2013	Tottenham	@	Southampton	5	0	0			0									0
10	Jermain Defoe J. Defoe	5/2/2015	Sunderland	vs	Southampton	82	0	0			0	0	2	1	0	35	0	1	0	0
11	Jermain Defoe J. Defoe	11/7/2015	Sunderland	vs	Southampton	16	0	0	0.00	0.00	0	0	0	0	0	2	0	0	0	0
12	Jermain Defoe J. Defoe	3/5/2016	Sunderland	@	Southampton	31	1	0	0.33	0.00	0	0	2	1	0	5	0	0	0	0
13	Jermain Defoe J. Defoe	8/27/2016	Sunderland	@	Southampton	90	1	0	0.84	0.00	1	0	2	1	0	25	5	0	1	0
14	Jermain Defoe J. Defoe	2/11/2017	Sunderland	vs	Southampton	90	0	0	0.00	0.00	0	0	0	0	0	25	4	1	0	0
15	Jermain Defoe J. Defoe	12/3/2017	Bournemouth	vs	Southampton	69	0	0	0.47	0.14	0	0	1	1	0	18	2	0	2	1
16	Jermain Defoe J. Defoe	4/28/2018	Bournemouth	@	Southampton	26	0	0	0.00	0.09	0	0	0	0	0	6	3	0	0	0
	Total					1,051	6	1			1									1